Michael P Hay Selected Research

IC87361

12/2019	Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia.
11/2019	Hypoxia-selective radiosensitisation by SN38023, a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361.

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Michael P Hay Research Topics

Disease

30	Hypoxia (Hypoxemia) 01/2022 - 01/2003
27	Neoplasms (Cancer) 01/2022 - 12/2003
4	Renal Cell Carcinoma (Grawitz Tumor) 01/2014 - 07/2008
3	Squamous Cell Carcinoma of Head and Neck 01/2022 - 12/2019
2	Breast Neoplasms (Breast Cancer) 10/2020 - 12/2018
2	Carcinoma (Carcinomatosis) 02/2005 - 01/2004
1	Body Weight (Weight, Body) 01/2022
1	Head and Neck Neoplasms (Head and Neck Cancer) 12/2020
1	Hypersensitivity (Allergy) 10/2020
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 04/2020
1	Migraine Disorders (Migraine) 04/2020
1	Cardiovascular Diseases (Cardiovascular Disease) 04/2020
1	Acidosis 07/2019
1	Acromegaly 01/2019
1	Triple Negative Breast Neoplasms 12/2018
1	Hypothermia 01/2017
1	Multiple Myeloma 01/2016
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 08/2013
1	Necrosis 01/2012
1	Colonic Neoplasms (Colon Cancer) 08/2006

Drug/Important Bio-Agent (IBA)

19	ProdrugsIBA 01/2022 - 12/2003
16	Tirapazamine (SR 4233)IBA 01/2022 - 01/2003
15	Pharmaceutical PreparationsIBA 12/2019 - 11/2003
11	Cytotoxins (Cytolysins)IBA 01/2022 - 01/2004
7	CEN-209IBA 01/2017 - 10/2010
6	Oxidoreductases (Dehydrogenase)IBA 10/2020 - 01/2006
6	OxidesIBA 07/2019 - 01/2004
5	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 11/2003
5	Oxygen (Dioxygen)IBA 01/2014 - 11/2008
4	azomycinIBA 04/2019 - 08/2013
3	Biomarkers (Surrogate Marker)IBA 12/2020 - 03/2012
3	NitroimidazolesIBA 04/2019 - 04/2014
3	Antineoplastic Agents (Antineoplastics)IBA 01/2017 - 06/2004
3	TriazinesIBA 01/2017 - 11/2008
2	IC87361IBA 12/2019 - 11/2019
2	4-nitroimidazoleIBA 01/2018 - 04/2014
2	EnzymesIBA 06/2013 - 01/2012
2	3-amino-1,2,4-benzotriazineIBA 03/2010 - 06/2005
2	Free RadicalsIBA 06/2005 - 11/2003
1	AZD7648IBA 01/2022
1	CopperIBA 10/2020
1	NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)IBA 10/2020
1	Hydroxyl RadicalIBA 10/2020
1	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 04/2020
1	olaparibIBA 12/2019
1	8- dibenzothiophen- 4- yl- 2- morpholin- 4- yl- chromen- 4- oneIBA 12/2019
1	veliparibIBA 12/2019
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 11/2019
1	formic acid (formate)IBA 11/2019
1	DNA-Activated Protein KinaseIBA 11/2019
1	AcidsIBA 07/2019
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 04/2019
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 04/2019
1	Phosphotransferases (Kinase)IBA 04/2019
1	CarbamatesIBA 04/2019
1	Protein Kinases (Protein Kinase)IBA 04/2019
1	Proteins (Proteins, Gene)FDA Link 04/2019
1	Dynamin IIIBA 12/2018
1	Dynamins (Dynamin)IBA 12/2018
1	DNA Repair EnzymesIBA 12/2018
1	Hydroxylamine (Hydroxylamine Hydrochloride)IBA 10/2018
1	imidazoleIBA 10/2018
1	TH 302IBA 10/2018
1	Phosphates (Orthophosphate)IBA 01/2018
1	AcridinesIBA 01/2016
1	SolutionsIBA 11/2014
1	SulfonamidesIBA 04/2014
1	Indicators and Reagents (Reagents)IBA 01/2014
1	BenzamidesIBA 01/2014
1	Glucose (Dextrose)FDA LinkGeneric 01/2014
1	Hemoglobins (Hemoglobin)IBA 08/2013
1	Therapeutic UsesIBA 08/2013
1	NitroreductasesIBA 06/2013
1	2- (2- nitro- 1H- imidazol- 1- yl)- N- (2,2,3,3,3- pentafluoropropyl)acetamideIBA 03/2012
1	tretazicarIBA 01/2012
1	Caspase 3 (Caspase-3)IBA 01/2012
1	Adenosine Triphosphate (ATP)IBA 08/2011
1	STF-31IBA 08/2011
1	aniline (aniline hydrobromide)IBA 06/2011
1	Aniline CompoundsIBA 06/2011
1	ThiazolesIBA 06/2011
1	NitrogenIBA 11/2008
1	STF 62247IBA 07/2008
1	Biological ProductsIBA 02/2005
1	Cisplatin (Platino)FDA LinkGeneric 01/2004
1	3-amino-1,2,4-benzotriazine-1-oxideIBA 01/2004

Therapy/Procedure

10	Therapeutics 12/2020 - 07/2008
6	Radiotherapy 01/2022 - 01/2004
4	Drug Therapy (Chemotherapy) 01/2022 - 01/2004
2	Aftercare (After-Treatment) 08/2013 - 08/2006
1	Precision Medicine 12/2020
1	Immunotherapy 12/2020